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Breast Cancer Cell Biology

Research results from Tunghai University, Department of Chemistry update understanding of breast cancer cell biology

Published in Cancer Weekly, April 13th, 2010

A report, 'Effects of peptidic antagonists of Grb2-SH2 on human breast cancer cells,' is newly published data in Protein and Peptide Letters. According to recent research published in the journal Protein and Peptide Letters, "The growth factor receptor-bound protein Src homology 2 (Grb2-SH2) plays an important role in the oncogenic Ras signaling pathway, which involves in cell proliferation and differentiation. Therefore, the antagonist of Grb2-SH2 has become a potential target for developing anticancer agents."

"Recently, we discovered a peptide 1 (Fmoc-Glu-Tyr-Aib-Asn-NH(2)) with high affinity for the Grb2-SH2 domain by using surface plasmon resonance...

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