Life Sciences
Research from Seoul National University, Cancer Research Institute SAS in the area of life sciences published
Published in Cancer Weekly, April 13th, 2010
Fresh data on life sciences are presented in the report 'Gq protein mediates UVB-induced cyclooxygenase-2 expression by stimulating HB-EGF secretion from HaCaT human keratinocytes.' According to recent research from Korea, "Ultraviolet (UV) radiation induces cyclooxygenase-2 expression to produce cellular responses including aging and carcinogenesis in skin. We hypothesised that heterotrimeric G proteins mediate UV-induced COX-2 expression by stimulating secretion of soluble HB-EGF (sHB-EGF)."
"In this study, we aimed to elucidate the role and underlying mechanism of the alpha subunit of Gq protein (Galphaq) in UVB-induced HB-EGF secretion and COX-2 induction. We found...
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Source: Cancer Weekly (2010-04-13)
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