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Gastric Cancer Genetics

Research reports from Iwate Medical University, Department of Pathology provide new insights into gastric cancer genetics

Published in Cancer Weekly, April 20th, 2010

New research, 'Molecular analysis of single isolated glands in gastric cancers and their surrounding gastric intestinal metaplastic mucosa,' is the subject of a report. According to a study from Japan, "The biological properties and underlying genetics of gastric cancer and gastric intestinal metaplasia evolve with neoplastic progression from the genetics of the original gland cell. PCR assay with crypt isolation was used in tumors from 20 patients to examine microsatellite alterations (allelic imbalance at 17p, 5q, 18q, 3p, 4p, and 9p, and microsatellite instability) in glands from each tumor and from intestinal metaplastic lesions."

"Tumor specimens were processed as...

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