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Studies from University Medical Center, Department of Medical Oncology yield new data on life sciences

Published in Cancer Weekly, May 4th, 2010

Data detailed in 'Cyclin B-Cdk1 activates its own pump to get into the nucleus' have been presented. "The transition to mitosis requires extensive nuclear and cytoplasmic rearrangements that must be spatially and temporally coordinated," scientists in Utrecht, Netherlands report.

"In this issue, Gavet and Pines (2010a. J. Cell Biol. doi:10.1083/jcb.200909144) report on a simple yet elegant mechanism as to how this is achieved. By monitoring the activity of cyclin B-Cdk1 in real time, the authors show that concomitant with its activation in the cytoplasm, the kinase complex is rapidly imported into the nucleus by modifying the activity of the nucleocytoplasmic transport...

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