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University of Michigan

Temperature-sensing protein linked to skin cancer, hirsutism

Published in Cancer Weekly, May 4th, 2010

ANN ARBOR, Mich.---New findings about a temperature sensor in the skin could lead to novel approaches to controlling excess hair growth and treating skin cancers.

The common denominator that unites these seemingly unrelated processes is a versatile protein called TRPV3. The new research shows that in addition to serving as a temperature sensor, the protein is important for proper hair growth and skin health. The work, by University of Michigan cell biologist Haoxing Xu and colleagues, is described in a paper published in the April 16 issue of the journal Cell.

Found mainly in cells called keratinocytes in the outer layer of skin, TRPV3 functions as a...

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