Proline-Directed Protein Kinases
Investigators at Indiana University, Department of Surgery release new data on proline-directed protein kinases
Published in Cancer Weekly, May 11th, 2010
Investigators publish new data in the report 'Targeting mitogen-activated protein kinase kinase with the inhibitor PD0325901 decreases hepatocellular carcinoma growth in vitro and in mouse model systems.' According to recent research published in the journal Hepatology, "Hepatocellular carcinoma (HCC) is a common cause of death from solid organ malignancy worldwide. Extracellular signal-regulated/mitogen-activated protein kinase kinase (MEK) signaling is a critical growth regulatory pathway in HCC."
"Targeting MEK with a novel small molecule inhibitor, PD0325901, may inhibit HCC tumorigenesis. PD0325901 (0.01-100 nM) inhibited growth and MEK activity in vitro in...
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Source: Cancer Weekly (2010-05-11)
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