Prostate Cancer

New research on prostate cancer from Baylor College of Medicine, College of Medicine summarized

Published in Cancer Weekly, May 18th, 2010

According to recent research from the United States, "Vitamin D receptor (VDR) agonists have been shown to reduce the growth of several prostate cancer cell lines. However, the effects of VDR activation have not been examined in the presence of the recently identified androgen-regulated TMPRSS2:ERG gene fusions, which occur in a high percentage of prostate cancers and play a role in growth and invasiveness."

"In a previous microarray study, we found that VDR activation induces TMPRSS2 expression in LNCaP prostate cancer cells. Here we show that the natural VDR agonist 1 alpha,25-dihydroxyvitamin D-3 and its synthetic analog EB1089 increase expression of TMPRSS2: ERG...

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Source: Cancer Weekly (2010-05-18)

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