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Prostate Cancer

Scientists find protein spurs spread of prostate cancer

Published in Cancer Weekly, June 1st, 2010

Researchers from the Kimmel Cancer Center at Jefferson have found that Stat5, a signaling protein previously found to be key to survival of prostate cancer, is also involved in metastasis.

Their study, published in the online edition of Endocrine-Related Cancer, demonstrates in both laboratory and animal models that nuclear Stat5 over-expression leads to a deadly spread of the cancer. They add that their work with mice was unique in that it was the first time Stat5 was associated with prostate cancer metastasis processes in an animal model.

"Until now, we thought that Stat5 was involved in primarily promoting tumor growth, but this study indicates it...

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