Prostate Cancer
Study results from Harbin Medical University, Department of Urology provide new insights into prostate cancer
Published in Cancer Weekly, June 1st, 2010
Researchers detail in 'TGF-beta1 reverses inhibition of COX-2 with NS398 and increases invasion in prostate cancer cells,' new data in prostate cancer. "Bone-derived transforming growth factor (TGF)-beta1 leads to tumor growth, osteoblastic lesions and more invasion. Degradation of basement membranes caused by cyclooxygenase (COX)-2 is known as a distinctive feature of invasive cells," scientists in Harbin, People's Republic of China report.
"We investigated inhibition of COX-2 with NS398 in PC-3 and LNCaP cell lines. TGF-beta1 and dmPGE2 were added in NS398 treated or untreated cells. COX-2 did not express in PC-3, after treatment with TGF-beta1, COX-2 appeared and...
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Source: Cancer Weekly (2010-06-01)
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