Diphtheria
New findings reported from Dalhousie University describe advances in diphtheria
Published in Cancer Weekly, June 1st, 2010
New investigation results, 'Sensitivity of cancer cells to truncated diphtheria toxin,' are detailed in a study published in Plos One. "Diphtheria toxin (DT) has been utilized as a prospective anti-cancer agent for the targeted delivery of cytotoxic therapy to otherwise untreatable neoplasia. DT is an extremely potent toxin for which the entry of a single molecule into a cell can be lethal," researchers in Halifax, Canada report.
"DT has been targeted to cancer cells by deleting the cell receptor-binding domain and combining the remaining catalytic portion with targeting proteins that selectively bind to the surface of cancer cells. It has been assumed that...
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Source: Cancer Weekly (2010-06-01)
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