Transcription Factors

Research conducted by R.S. Giri and co-researchers has updated our knowledge about transcription factors

Published in Cancer Weekly, June 1st, 2010

According to a study from India, "In an attempt to discover novel inhibitors of NF-kappa B and AP-1 mediated transcriptional activation utilizing the concept of chemical lead based medicinal chemistry and bioisosterism a series of 2-(2,3-disubstituted-thiophen-5-yl)-3H-quinazolin-4-one analogs was designed. A facile and simple route for the synthesis of the designed molecules was developed."

"Synthesized molecules were evaluated for their activity as inhibitors towards NF-kappa B and AP-1 mediated transcriptional activation in a cell line report-based assay. This series provides us with a substantial number of compounds inhibiting the activity of NF-kappa B and/or AP-1...

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Source: Cancer Weekly (2010-06-01)

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