Proline-Directed Protein Kinases
Findings from University catholique of Louvain provide new insights into proline-directed protein kinases
Published in Cancer Weekly, June 1st, 2010
Researchers detail in 'Active and passive tumor targeting of a novel poorly soluble cyclin dependent kinase inhibitor, JNJ-7706621,' new data in proline-directed protein kinases. According to a study from Brussels, Belgium, "The anti-cancer cyclin dependent kinase (CDK) inhibitors are poorly soluble drugs. The aims of this work were (i) to formulate a novel CDK inhibitor, JNJ-7706621, in polymeric micelles and nanoparticles, (ii) to compare passive and active targeting on tumor growth and (iii) to evaluate the potential synergy of JNJ-7706621 with Paclitaxel."
"Therefore, JNJ-7706621 was encapsulated in self-assembling diblock copolymers made up of epsilon-caprolactone...
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Source: Cancer Weekly (2010-06-01)
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