Clinical Trial Research
New clinical trial research study findings recently were published by G. Locatelli and co-researchers
Published in Cancer Weekly, June 1st, 2010
A new study, 'Transcriptional analysis of an E2F gene signature as a biomarker of activity of the cyclin-dependent kinase inhibitor PHA-793887 in tumor and skin biopsies from a phase I clinical study,' is now available. "A transcriptional signature of the pan-cyclin-dependent kinase (Cdk) inhibitor PHA-793887 was evaluated as a potential pharmacodynamic and/or response biomarker in tumor and skin biopsies from patients treated in a phase I clinical study. We first analyzed the expression of a number of known E2F-dependent genes that were predicted to be modulated after Cdk2 and Cdk4 inhibition in xenograft tumor and skin samples of mice treated with the compound," scientists in Italy...
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Source: Cancer Weekly (2010-06-01)
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