Breast Cancer
New data from University of Washington, Department of Pharmaceutics illuminate research in breast cancer
Published in Cancer Weekly, June 1st, 2010
Research findings, 'Role of basic residues within or near the predicted transmembrane helix 2 of the human breast cancer resistance protein in drug transport,' are discussed in a new report. "The human breast cancer resistance protein (BCRP/ABCG2) mediates efflux of drugs and xenobiotics out of cells. In this study, we investigated the role of five basic residues within or near transmembrane ™ 2 of BCRP in transport activity," scientists in the United States report.
"Lys(452), Lys(453), His(457), Arg(465), and Lys(473) were replaced with Ala or Asp. K452A, K453D, H457A, R465A, and K473A were stably expressed in human embryonic kidney (HEK) cells, and their plasma...
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Source: Cancer Weekly (2010-06-01)
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