Enzymes and Coenzymes
New research on enzymes and coenzymes from Gifu Pharmaceutical University summarized
Published in Cancer Weekly, June 1st, 2010
Investigators publish new data in the report 'Selective inhibition of the tumor marker AKR1B10 by antiinflammatory N-phenylanthranilic acids and glycyrrhetic acid.' According to recent research from Gifu, Japan, "A human aldose reductase-like protein, AKR1B10 in the aldo-keto reductase (AKR) superfamily, was recently identified as a tumor marker of several types of cancer. Tolrestat, an aldose reductase inhibitor (ARI), is known to be the most potent inhibitor of the enzyme."
"In this study, we compared the inhibitory effects of other ARIs including flavonoids on AKR1B10 and aldose reductase to evaluate their specificity. However, ARIs showed lower inhibitory potency...
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Source: Cancer Weekly (2010-06-01)
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