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Cancer Therapy

Research from China Pharmaceutical University has provided new data on cancer therapy

Published in Cancer Weekly, June 1st, 2010

Data detailed in 'Synthesis and evaluation of nitric oxide-releasing derivatives of farnesylthiosalicylic acid as anti-tumor agents' have been presented. According to recent research published in the journal Bioorganic & Medicinal Chemistry, "Novel furoxan-based nitric oxide (NO)-releasing derivatives (11a-p) of farnesylthiosalicylic acid (FTA) were synthesized. Compounds 11d, 11f, 11k, and 11m-o displayed anti-tumor activities superior to FTA and sorafenib in most cancer cells tested."

"Analysis of six compounds revealed that 11d, 11f, 11n, 11o, and 11p, but not 11a that had low anti-tumor activity, produced high levels of NO, associated with their strong...

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