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Membrane Glycoproteins

Research reports from University of Buenos Aires, Institute of Oncology provide new insights into membrane glycoproteins

Published in Cancer Weekly, June 1st, 2010

Fresh data on membrane glycoproteins are presented in the report 'The neural cell adhesion molecule is involved in the metastatic capacity in a murine model of lung cancer.' According to a study from Buenos Aires, Argentina, "Neural cell adhesion molecule (NCAM) is involved in cell growth, migration, and differentiation. Its expression and/or polysialylation appear to be deregulated in many different cancer types."

"We employed the lung tumor cell line LP07, syngeneic in BALB/c mice to investigate the role of NCAM in malignant progression. LP07 cells express the three main NCAM isoforms, all of them polysialylated. This cells line, pretreated with an anti-NCAM antibody...

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