Stem Cell Research
Research on stem cell research detailed by scientists at Dana-Farber Cancer Institute, Department of Medical Oncology
Published in Cancer Weekly, June 8th, 2010
New research, 'PLAGL2 regulates Wnt signaling to impede differentiation in neural stem cells and gliomas,' is the subject of a report. "A hallmark feature of glioblastoma is its strong self-renewal potential and immature differentiation state, which contributes to its plasticity and therapeutic resistance. Here, integrated genomic and biological analyses identified PLAGL2 as a potent protooncogene targeted for amplification/gain in malignant gliomas," scientists in the United States report.
"Enhanced PLAGL2 expression strongly suppresses neural stem cell (NSC) and glioma-initiating cell differentiation while promoting their self-renewal capacity upon differentiation...
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Source: Cancer Weekly (2010-06-08)
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