Vitronectin Receptors
Study findings from Scripps Research Institute provide new insights into vitronectin receptors
Published in Cancer Weekly, June 15th, 2010
Researchers detail in 'Targeting activated integrin alphavbeta3 with patient-derived antibodies impacts late-stage multiorgan metastasis,' new data in vitronectin receptors. "Advanced metastatic disease is difficult to manage and specific therapeutic targets are rare. We showed earlier that metastatic breast cancer cells use the activated conformer of adhesion receptor integrin alphavbeta3 for dissemination," scientists in the United States report.
"We now investigated if targeting this form of the receptor can impact advanced metastatic disease, and we analyzed the mechanisms involved. Treatment of advanced multi-organ metastasis in SCID mice with patient-derived scFv...
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Source: Cancer Weekly (2010-06-15)
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