Melanoma

New melanoma study findings recently were reported by researchers at Moffitt Cancer Center

Published in Cancer Weekly, June 29th, 2010

A report, 'Recovery of phospho-ERK activity allows melanoma cells to escape from BRAF inhibitor therapy,' is newly published data in British Journal of Cancer. According to recent research from the United States, "Resistance to BRAF inhibitors is an emerging problem in the melanoma field. Strategies to prevent and overcome resistance are urgently required."

"The dynamics of cell signalling, BrdU incorporation and cell-cycle entry after BRAF inhibition was measured using flow cytometry and western blot. The ability of combined BRAF/MEK inhibition to prevent the emergence of resistance was demonstrated by apoptosis and colony formation assays and in 3D organotypic...

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Source: Cancer Weekly (2010-06-29)

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