Colitis
New findings in colitis described from Harvard University
Published in Cancer Weekly, September 28th, 2010
New research, 'Colitis-associated colorectal cancer driven by T-bet deficiency in dendritic cells,' is the subject of a report. "We previously described a mouse model of ulcerative colitis linked to T-bet deficiency in the innate immune system. Here, we report that the majority of T-bet(-/-)RAG2(-/-) ulcerative colitis (TRUC) mice spontaneously progress to colonic dysplasia and rectal adenocarcinoma solely as a consequence of MyD88-independent intestinal inflammation," investigators in the United States report.
"Dendritic cells (DCs) are necessary cellular effectors for a proinflammatory program that is carcinogenic. Whereas these malignancies arise in the setting of a...
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Source: Cancer Weekly (2010-09-28)
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