Squamous Cell Carcinoma
Reports from Johannes Gutenberg University add new data to research in squamous cell carcinoma
Published in Cancer Weekly, September 28th, 2010
Data detailed in 'Demethylation treatment restores hic1 expression and impairs aggressiveness of head and neck squamous cell carcinoma' have been presented. According to a study from Mainz, Germany, "Promoter hypermethylation of tumor suppressor genes is a common feature of primary cancer cells. However, at date the somatic epigenetic events that occur in head and neck squamous cell carcinoma (HNSCC) tumorigenesis are not yet been well defined."
"In the present study we analysed the methylation status of the gene hypermethylated in cancer-1 (hic1), a gene located on chromosome 17p13.3, a region frequently lost in HNSCC. We analysed 22 HNSCC samples and three cell lines...
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Source: Cancer Weekly (2010-09-28)
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