Stem Cell Research
New stem cell research from Chinese Academy of Medical Science described
Published in Cancer Weekly, October 12th, 2010
"Acute myeloid leukemia (AML) arises from genetic changes at the level of stem cell, various mutations have been elucidated, including AML1-ETO fusion gene has been shown as the representative target of cellular transformation for LSCs originating from hematopoietic stem cells (HSCs) compartment. LSCs resemble HSCs with respect to self-renewal capacity and chemotherapy-resistance. However," investigators in Tianjin, People's Republic of China report.
"LSCs possess specific cell-surface markers, they are proposed to reside within the CD34(+)/CD38(-)/CD123(+). compartment. And the interaction mediated by adhesion molecules between LSCs and niche played a role in...
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Source: Cancer Weekly (2010-10-12)
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