Serous Carcinoma

Findings from S.G. Jung and co-authors broaden understanding of serous carcinoma

Published in Cancer Weekly, October 19th, 2010

"The Notch signaling pathway is an important cell signaling system, which regulates cell differentiation, proliferation, and apoptosis, and is aberrantly activated in a wide range of cancer, including ovarian cancers. However, it remains unclear as to whether Notch signaling plays a role in the progression and prognosis of ovarian cancer," scientists in South Korea report.

"We examined the mRNA and protein expression of Notch 3, Jagged 1, and Jagged 2 in 98 ovarian epithelial tumors via real-time PCR and in 175 tumors with immunohistochemical analysis, and then correlated their expression levels with clinicopathological parameters and patient survival. In this study, we...

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Source: Cancer Weekly (2010-10-19)

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