Genetics and Colon Cancer
Research from Sapporo Medical University, Department of Biochemistry broadens understanding of genetics and colon cancer
Published in Cancer Weekly, November 2nd, 2010
Investigators publish new data in the report 'Epigenetic drivers of genetic alterations.' "DNA methylation plays a key role in the silencing of cancer-related genes, thereby affecting numerous cellular processes, including the cell cycle checkpoint, apoptosis, signal transduction, cell adhesion, and angiogenesis. DNA methylation also affects the expression of genes involved in maintaining the integrity of the genome through DNA repair and detoxification of reactive oxygen species," scientists writing in the journal Advances In Genetics report.
"Here, we discuss how epigenetic changes lead to genetic alterations, including microsatellite instability and nucleotide...
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Source: Cancer Weekly (2010-11-02)
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