B-Cell Lymphoma
Data on B-cell lymphoma published by researchers at Columbia University, Herbert Irving Comprehensive Cancer Center
Published in Cancer Weekly, November 23rd, 2010
Investigators publish new data in the report 'Targeted disruption of the S1P2 sphingosine 1-phosphate receptor gene leads to diffuse large B-cell lymphoma formation.' According to recent research from the United States, "S1P(2) sphingosine 1-phosphate receptor signaling can regulate proliferation, survival, morphology, and migration in many cell types in vitro. Here, we report that S1P(2)(-/-) mice develop clonal B-cell lymphomas with age, such that approximately half of the animals display this neoplasm by 1.5 to 2 years of age."
"Histologic, immunophenotypic, and molecular analyses revealed a uniform tumor phenotype with features of germinal center (GC)-derived...
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Source: Cancer Weekly (2010-11-23)
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