Colon Cancer
Studies from S. Jaramillo and colleagues yield new information about colon cancer
Published in Cancer Weekly, November 23rd, 2010
"The aim of this study was to determine whether isorhamnetin, an immediate 3'-O-methylated metabolite of quercetin, affects proliferation, cell death, and the cell cycle of human colon carcinoma (HCT-116) cells. Isorhamnetin was found to be a potent antiproliferative agent in a dose- and time-dependent manner, with an IC50 of 72 mc M after 48 h of incubation as estimated by MU assay," scientists writing in the Journal of Agricultural and Food Chemistry report.
"Flow cytometry and fluorescence microscopy analysis showed that isorhamnetin exerted a stimulatory effect on apoptosis and necrosis. Isorhamnetin also increased the number of cells in G2/M phase. Serum...
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Source: Cancer Weekly (2010-11-23)
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