Prostate Cancer

Findings from Lund University broaden understanding of prostate cancer

Published in Cancer Weekly, January 11th, 2011

2011 JAN 11 -- "MicroRNAs (miRNAs) are small noncoding RNAs that post-transcriptionally regulate gene expression. There have been several reports of miRNA deregulation in prostate cancer (PCa) and the biological evidence for an involvement of miRNAs in prostate tumorigenesis is increasing," researchers in Malmo, Sweden report.

"In this study, we show that miR-34c is downregulated in PCa (p = 0.0005) by performing qRT-PCR on 49 TURPs from PCa patients compared to 25 from patients with benign prostatic hyperplasia. The miR-34c expression was found to inversely correlate to aggressiveness of the tumor, WHO grade, PSA levels and occurrence of metastases....

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Source: Cancer Weekly (2011-01-11)

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