Carcinogenesis
University of Maryland Reports Research in Carcinogenesis
Published in Cancer Weekly, February 15th, 2011
2011 FEB 15 -- Scientists discuss in 'Inactivation of the quinone oxidoreductases NQO1 and NQO2 strongly elevates the incidence and multiplicity of chemically induced skin tumors' new findings in Carcinogenesis. "The cytosolic quinone oxidoreductases NQO1 and NQO2 protect cells against oxidative stress by detoxifying quinones and preventing redox cycling. In this study, we used double knockout (DKO) mice deficient for NQO1 and NQO2 to investigate the role of these antioxidative enzymes in a two-stage model of inflammatory skin carcinogenesis," scientists writing in the journal Cancer Research report.
"In this model, tumors are caused by exposure to...
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Source: Cancer Weekly (2011-02-15)
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