Hereditary Nonpolyposis Colorectal Cancer
Mayo Clinic Reports Research in Hereditary Nonpolyposis Colorectal Cancer
Published in Cancer Weekly, February 15th, 2011
2011 FEB 15 -- A report, 'Frequency of deletions of EPCAM (TACSTD1) in MSH2-associated lynch syndrome cases,' is newly published data in The Journal of Molecular Diagnostics. "Lynch syndrome is an autosomal dominant cancer predisposition syndrome characterized by loss of function of DNA mismatch repair enzyme MLH1, MSH2, MSH6, or PMS2. Mutations in MLH1 and MSH2 account for ~80% of the inherited cases," scientists in the United States report.
"However, in up to 20% of cases suspected of having a germline mutation in MSH2 due to loss of MSH2 expression, a germline mutation is not identified. Recent studies have shown that some Lynch syndrome cases are...
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Source: Cancer Weekly (2011-02-15)
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