Nephrology
Findings from Institute of Cancer Research Advance Knowledge in Nephrology
Published in Cancer Weekly, February 22nd, 2011
2011 FEB 22 -- A new study, 'p21 loss blocks senescence following Apc loss and provokes tumourigenesis in the renal but not the intestinal epithelium,' is now available. According to recent research from Glasgow, the United Kingdom, "Senescence has been implicated as an important mechanism of tumor suppression in a number of human malignancies, including colorectal cancer (CRC). However, we still have a relatively poor understanding of how the underlying mutations that occur in cancer cause senescence and its relevance in vivo."
"The Apc gene is mutated in approximately 80% of CRC as the initiating event, but rarely elsewhere. In this study we have examined...
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Source: Cancer Weekly (2011-02-22)
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