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Prostate Cancer

Data from Yale University Advance Knowledge in Prostate Cancer

Published in Cancer Weekly, March 15th, 2011

2011 MAR 15 -- Investigators publish new data in the report 'Genome-wide methylation analysis identifies involvement of TNF-a mediated cancer pathways in prostate cancer.' "Altered signaling pathways resulting from aberrant changes in epigenetic parameters may play a pivotal role in carcinogenesis. To identify biological pathways likely to be affected by methylation-mediated alterations in gene expression in prostate cancer, we performed a genome-wide methylation analysis of 27,578 CpG sites, corresponding to 14,495 genes on a pooled sample of 12 pairs of prostate tumor and adjacent normal tissues," researchers in the United States report.

"In all, 972 CpG...

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