Metaplasia
Researchers' Work from Vanderbilt University Medical Center Focuses on Metaplasia
Published in Cancer Weekly, March 29th, 2011
2011 MAR 29 -- Researchers detail in 'Epithelial tissues have varying degrees of susceptibility to Kras(G12D)-initiated tumorigenesis in a mouse model,' new data in Metaplasia. According to recent research published in the journal Plos One, "Activating mutations in the Kras gene are commonly found in some but not all epithelial cancers. In order to understand the susceptibility of different epithelial tissues to Kras-induced tumorigenesis, we introduced one of the most common Kras mutations, Kras(G12D), broadly in epithelial tissues."
"We used a mouse model in which the G12D mutation is placed in the endogenous Kras locus controlled by inducible,...
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Source: Cancer Weekly (2011-03-29)
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