Bladder Cancer

Studies from R.R. Serizawa and Colleagues Provide New Data on Bladder Cancer

Published in Cancer Weekly, June 21st, 2011

2011 JUN 21 -- "The bladder cancer genome harbors numerous oncogenic mutations and aberrantly methylated gene promoters. The aim of our study was to generate a profile of these alterations and investigate their use as biomarkers in urine sediments for noninvasive detection of bladder cancer," scientists writing in the International Journal of Cancer report.

"We systematically screened FGFR3, PIK3CA, TP53, HRAS, NRAS and KRAS for mutations and quantitatively assessed the methylation status of APC, ARF, DBC1, INK4A, RARB, RASSF1A, SFRP1, SFRP2, SFRP4, SFRP5 and WIF1 in a prospective series of tumor biopsies (N = 105) and urine samples (N = 113) from...

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Source: Cancer Weekly (2011-06-21)

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