Research from North Carolina State University Yields New Data on Skin Cancer

2011 JUL 19 -- Data detailed in "C/EBPa expression is downregulated in human nonmelanoma skin cancers and inactivation of C/EBPa confers susceptibility to UVB-induced skin squamous cell carcinomas" have been presented. According to the authors of a study from Raleigh, North Carolina, "Human epidermis is routinely subjected to DNA damage induced by UVB solar radiation. Cell culture studies have revealed an unexpected role for C/EBPa (CCAAT/enhancer-binding protein-a) in the DNA damage response network, where C/EBPa is induced following UVB DNA damage, regulates the G(1) checkpoint, and diminished or ablated expression of C/EBPa results in G(1) checkpoint failure."

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