Clinical Oncology

Research Results from Charles University Update Knowledge of Clinical Oncology

Published in Cancer Weekly, August 16th, 2011

2011 AUG 16 -- "Li-Fraumeni syndrome is a rare autosomal dominant cancer predisposition syndrome characterized by a broad spectrum of tumors. The disorder is caused by germline mutations in the TP53 gene," researchers in Prague, Czech Republic report.

"We studied chromosomes in the sperm of two male carriers of TP53 mutations. We observed increased sperm aneuploidy, mainly concerning the gonosomes when compared to four normal male controls," wrote P. Paulasova and colleagues, Charles University.

The researchers concluded: "This observation may correlate with the involvement of the p53 protein in spermatogenesis, with its role in...

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Source: Cancer Weekly (2011-08-16)

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