Leukemia
Investigators at Kaiser Permanente Zero in on Leukemia
Published in Cancer Weekly, August 30th, 2011
2011 AUG 30 -- According to the authors of recent research from Roseville, California, "Folate is involved in the one-carbon metabolism that plays an essential role in the synthesis, repair, and methylation of DNA. We examined whether child's germline genetic variation in the folate pathway is associated with childhood acute lymphoblastic leukemia (ALL), and whether periconception maternal folate and alcohol intake modify the risk."
"Seventy-six single nucleotide polymorphisms (SNPs), including 66 haplotype-tagging SNPs in 10 genes (CBS, DHFR, FOLH1, MTHFD1, MTHFR, MTR, MTRR, SHMT1, SLC19A1, and TYMS), were genotyped in 377 ALL cases and 448 controls....
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Source: Cancer Weekly (2011-08-30)
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