Colon Cancer
Scientists at Ludwig-Maximilians University Target Colon Cancer
Published in Cancer Weekly, October 4th, 2011
2011 OCT 4 -- Fresh data on Colon Cancer are presented in the report "Up and downregulation of p16(Ink4a) expression in BRAF-mutated polyps/adenomas indicates a senescence barrier in the serrated route to colon cancer." According to the authors of a study from Munich, Germany, "P16(Ink4a) is an important factor in carcinogenesis and its expression can be linked to oncogene-induced senescence. Oncogene-induced senescence is characterized by growth arrest and occurs as a consequence of oncogene activation due to KRAS or BRAF mutation."
"It has been shown that the induction of p16(Ink4a) in premalignant lesions and its loss during malignant transformation is...
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Source: Cancer Weekly (2011-10-04)
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