Cancer Research

Study Results from D. Vergara and Colleagues in the Area of Cancer Research Published

Published in Cancer Weekly, October 11th, 2011

2011 OCT 11 -- According to the authors of a study from Palermo, Italy, "Carcinoma progression is associated with the loss of epithelial features, and the acquisition of a mesenchymal phenotype by tumour cells. Herein we show that exposure of MCF-7 cells to epidermal growth factor (EGF) resulted in morphological alterations characteristic of epithelial-to-mesenchymal transition (EMT)."

"EGF treatment resulted in increased motility along with an up-regulation of transcription factors Slug, Zeb1, Zeb2, and mesenchymal markers Vimentin and N-cadherin. Treatment of MCF-7 cells with a combined stimulation of EGF and resveratrol, a naturally occurring stilbene...

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Source: Cancer Weekly (2011-10-11)

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