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Prostate Cancer

Gene may be good target for tough-to-kill prostate cancer cells

Published in Cancer Weekly, October 11th, 2011

2011 OCT 11 -- WEST LAFAYETTE, Ind. - Purdue University scientists believe they have found an effective target for killing late-stage, metastatic prostate cancer cells.

Xiaoqi Liu, an assistant professor of biochemistry and member of Purdue's Center for Cancer Research, and graduate student Shawn Liu are focusing on the function of a gene called Polo-like kinase (Plk1), a critical regulator of the cell cycle. Plk1 is also an oncogene, which tends to mutate and can cause cancer.

The researchers found that later-stage prostate cancer cells are missing Pten, a tumor-suppressor gene. The loss of Pten causes problems during cell division....

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