Cell Biology

Studies by T. De Raedt and Co-Authors Describe New Findings in Cell Biology

Published in Cancer Weekly, October 25th, 2011

2011 OCT 25 -- "Ras-driven tumors are often refractory to conventional therapies. Here we identify a promising targeted therapeutic strategy for two Ras-driven cancers: Nf1-deficient malignancies and Kras/p53 mutant lung cancer," researchers in Cambridge, Massachusetts report.

"We show that agents that enhance proteotoxic stress, including the HSP90 inhibitor IPI-504, induce tumor regression in aggressive mouse models, but only when combined with rapamycin. These agents synergize by promoting irresolvable ER stress, resulting in catastrophic ER and mitochondrial damage. This process is fueled by oxidative stress, which is caused by IPI-504-dependent...

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Source: Cancer Weekly (2011-10-25)

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