Life Science Research
Research on Life Science Research Reported by Scientists at Queen Mary-University of London
Published in Cancer Weekly, November 1st, 2011
2011 NOV 1 -- Research findings, "Widespread expression of BORIS/CTCFL in normal and cancer cells," are discussed in a new report. According to the authors of a study from London, United Kingdom, "BORIS (CTCFL) is the paralog of CTCF (CCCTC-binding factor; NM_006565), a ubiquitously expressed DNA-binding protein with diverse roles in gene expression and chromatin organisation. BORIS and CTCF have virtually identical zinc finger domains, yet display major differences in their respective C-and N-terminal regions."
"Unlike CTCF, BORIS expression has been reported only in the testis and certain malignancies, leading to its classification as a 'cancer-testis'...
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Source: Cancer Weekly (2011-11-01)
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