Breast Cancer

Research from J. del Valle and Co-Researchers in the Area of Breast Cancer Described

Published in Cancer Weekly, November 1st, 2011

2011 NOV 1 -- "In this study, we present a novel complex rearrangement in the BRCA1 gene. The genomic rearrangement was identified using one of the two commercially available MLPA BRCA1 kits but was not confirmed with the other," researchers in Girona, Spain report.

"In this report, we present the full characterization at the DNA and RNA levels of a new partial deletion of exon 20 of BRCA1. This is a complex deletion with four breakpoints which promotes aberrant splicing with partial deletion of exon 20 plus the insertion of a cryptic exon corresponding to a fragment of intron 20," wrote Valle J. del and colleagues.

The researchers...

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Source: Cancer Weekly (2011-11-01)

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