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Colon Cancer

Reports from Shiraz University of Medical Sciences Describe Recent Advances in Colon Cancer

Published in Cancer Weekly, November 8th, 2011

2011 NOV 8 -- "Gene silencing due to DNA hypermethylation is a major mechanism for loss of tumor suppressor genes function in colorectal cancer. Activating V600E mutation in BRAF gene has been linked with widespread methylation of CpG islands in sporadic colorectal cancers," scientists writing in the journal Pathology & Oncology Research report.

"The aim of the present study was to evaluate the methylation status of three cancer-related genes, APC2, p14ARF, and ECAD in colorectal carcinogenesis and their association with the mutational status of BRAF and KRAS among Iranian colorectal cancer patients. DNA from 110 unselected series of sporadic...

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