Pancreatic Cancer
Studies from University of California Provide New Data on Pancreatic Cancer
Published in Cancer Weekly, November 15th, 2011
2011 NOV 15 -- "An essential regulator of gene transcription, nuclear receptor liver receptor homologue 1 (LRH-1) controls cell differentiation in the developing pancreas and maintains cholesterol homeostasis in adults. Recent genome-wide association studies linked mutations in the LRH-1 gene and its up-stream regulatory regions to development of pancreatic cancer," scientists in San Francisco, California report.
"In this work, we show that LRH-1 transcription is activated up to 30-fold in human pancreatic cancer cells compared to normal pancreatic ductal epithelium. This activation correlates with markedly increased LRH-1 protein expression in human...
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Source: Cancer Weekly (2011-11-15)
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