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Lung Cancer

Data from Pontifical Catholic University Advance Knowledge in Lung Cancer

Published in Cancer Weekly, November 22nd, 2011

2011 NOV 22 -- "Purpose Cofilin is a cytoskeletal protein whose overexpression has been associated with aggressiveness in several types of malignancies. Here, we established and optimized a simple semi-quantitative immunohistochemistry (SQ-IHC) method for cofilin quantification in tumor biopsies, and applied it in a retrospective cohort of NSCLC patients aiming at validating the use of cofilin-1 as a prognostic biomarker," scientists writing in the Journal of Cancer Research and Clinical Oncology report.

"Methods The SQ-IHC method for cofilin-1 quantification was established and applied in a NSCLC cohort. An archival collection of biopsies from 50...

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