One-Carbon Group Transferases

New Findings from H.M. O'Hagan and Co-Authors in the Area of One-Carbon Group Transferases Published

Published in Cancer Weekly, December 27th, 2011

2011 DEC 27 -- "Cancer cells simultaneously harbor global losses and gains in DNA methylation. We demonstrate that inducing cellular oxidative stress by hydrogen peroxide treatment recruits DNA methyltransferase 1 (DNMT1) to damaged chromatin," scientists in Liege, Belgium report.

"DNMT1 becomes part of a complex(es) containing DNMT3B and members of the polycomb repressive complex 4. Hydrogen peroxide treatment causes relocalization of these proteins from non-GC-rich to GC-rich areas. Key components are similarly enriched at gene promoters in an in vivo colitis model. Although high-expression genes enriched for members of the complex have histone mark and...

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Source: Cancer Weekly (2011-12-27)

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