Cytoskeleton

Researchers at Sapienza-University Publish New Data on Cytoskeleton

Published in Cancer Weekly, January 10th, 2012

2012 JAN 10 -- According to the authors of recent research published in the journal Molecular Cancer, "Aurora-A is an oncogenic kinase playing well-documented roles in mitotic spindle organisation. We previously found that Aurora-A inactivation yields the formation of spindles with fragmented poles that can drive chromosome mis-segregation."

"Here we have addressed the mechanism through which Aurora-A activity regulates the structure and cohesion of spindle poles. We inactivated Aurora-A in human U2OS osteosarcoma cells either by RNA-interference-mediated silencing or treating cultures with the specific inhibitor MLN8237. We show that mitotic spindle...

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Source: Cancer Weekly (2012-01-10)

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