Published in Cancer Weekly, January 31st, 2012
"To investigate the role of BRCA1 RING function in tumor suppression and therapy response, we introduced the Brca1(C61G) mutation in a conditional mouse model for BRCA1 -associated breast cancer. In contrast to BRCA1 -deficient mammary carcinomas, tumors carrying the Brca1(C61G) mutation responded poorly to platinum drugs...
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