Cell Biology

Data on Cell Biology Published by Researchers at King's College

Published in Cancer Weekly, January 31st, 2012

2012 JAN 31 -- According to the authors of a study from London, United Kingdom, "Hereditary breast cancers are frequently caused by germline BRCA1 mutations. The BRCA1(C61G) mutation in the BRCA1 RING domain is a common pathogenic missense variant, which reduces BRCA1/BARD1 heterodimerization and abrogates its ubiquitin ligase activity."

"To investigate the role of BRCA1 RING function in tumor suppression and therapy response, we introduced the Brca1(C61G) mutation in a conditional mouse model for BRCA1 -associated breast cancer. In contrast to BRCA1 -deficient mammary carcinomas, tumors carrying the Brca1(C61G) mutation responded poorly to platinum drugs...

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Source: Cancer Weekly (2012-01-31)

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