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Dermatology

Reports from N.N. Chen and Colleagues Advance Knowledge in Dermatology

Published in Cancer Weekly, February 7th, 2012

2012 FEB 7 -- According to the authors of recent research published in the journal Experimental Dermatology, "The effect of all-trans retinoic acid (ATRA) on cutaneous squamous cell carcinomas (c-SCC) has been poorly described. Because the imbalance of CRABP-II-mediated anticancer signalling and FABP5-mediated growth-promoting signalling was supposed to be related with ATRA sensitivities of cancer cells, COLO16 human c-SCC cell line was selected to check underlying mechanism leading to ATRA resistance by multiple experimental approaches."

"The results revealed that COLO 16 cells were resistant to 15 mu m ATRA treatment. FABP5 as well as the elements...

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